Soluble guanylate cyclase activators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/4545 (2006.01) A61K 31/506 (2006.01) A61P 9/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2753434

This inventions relates to compounds having the structure Formula I I and pharmaceutically acceptable salts thereof which are soluble guanylate cy-clase activators. The compounds are useful for treatment or prevention of cardiovascu-lar diseases, endothelial dysfunction, dias-tolic dysfunction, atherosclerosis, hyper-tension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocar-dial infarction, strokes, cardiac insufficien-cy, pulmonary hypertonia, erectile dys-function, asthma bronchiale, chronic kid-ney insufficiency, diabetes, or cirrhosis of the liver.

Cette invention porte sur des composés ayant la formule de structure II et sur leurs sels pharmaceutiquement acceptables qui sont des activateurs solubles de guanylate cyclase. Les composés sont utiles pour le traitement ou la prévention de maladies cardiovasculaires, d'un dysfonctionnement endothélial, d'un dysfonctionnement diastolique, d'une athérosclérose, d'une hypertension, d'une hypertension pulmonaire, d'une angine de poitrine, de thromboses, d'une resténose, d'un infarctus du myocarde, d'accidents vasculaires cérébraux, d'une insuffisance cardiaque, d'une hypertonie pulmonaire, d'un dysfonctionnement érectile, de l'asthme bronchique, d'une insuffisance rénale chronique, du diabète ou d'une cirrhose du foie.

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