Soluble her2 and her3 splice variant proteins,...

Details Soluble her2 and her3 splice variant proteins,... Soluble her2 and her3 splice variant proteins,...

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/71 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2689602

Soluble epidermal growth factor receptors 2 and 3 (HER2 and HER3) splice variant proteins with HER2 and HER3 antagonist activity and anti-proliferative properties, as well as the corresponding nucleic acids, are provided for treatment of proliferative diseases, in particular cancer. Also provided are compositions and methods for inducing expression of these splice variants, including splice switching oligonucleotides that modulate splicing of pre-mRNA that codes for these receptors.

L'invention concerne des récepteurs 2 et 3 (HER2 et HER3) de facteur de croissance épidermique solubles et des protéines à variante d'épissure ayant une activité antagoniste à l'égard de HER2 et HER3, ainsi que des acides nucléiques correspondants utilisés dans le traitement de maladies prolifératives, en particulier le cancer. Sont également décrites des compositions et des méthodes permettant d'induire l'expression de ces variantes d'épissure, dont des oligonucléotides à permutation d'épissage qui modulent l'épissage du pré-ARNm pour ces récepteurs.

Affiliated with

Also associated with

Rating

Soluble her2 and her3 splice variant proteins,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Soluble her2 and her3 splice variant proteins,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Soluble her2 and her3 splice variant proteins,... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1922740