Soluble hirudin conjugates

Details Soluble hirudin conjugates Soluble hirudin conjugates

C - Chemistry, Metallurgy

07

K

C07K 17/06 (2006.01) A61K 38/58 (2006.01) A61K 47/48 (2006.01) A61L 27/00 (2006.01) A61L 33/00 (2006.01)

Patent

CA 2092540

2092540 9205748 PCTABS00011 Disclosed is a soluble, biocompatible, pharmacological agent for inhibiting thrombin generation and thrombus formation, and methods for producing the same. The pharmacological agent or conjugate includes a soluble, biocompatible carrier and a thrombogenesis inhibitor immobilized thereto via a component of the carrier which binds the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or active fragment thereof. The thrombogenesis inhibitor may be bound to the component of the carrier via a bifunctional cross-linking reagent.

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