C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A01K 67/027 (2006.01) A61K 35/28 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2518549
The present invention relates to a soluble hybrid protein, comprising at least a first polypeptide sequence derived from a prion protein PrPc that is capable of binding a protein responsible for transmissible spongiform encephalitis (PrPsc), and a second polypeptide sequence (tag), wherein said hybrid protein does not comprise a functional membrane anchor moiety. Also, the present invention is directed to the use of said hybrid proteins for the diagnosis of transmissible spongiform encephalopathies. In addition, the present invention relates to the use of said hybrid protein, a nucleic acid encoding said hybrid protein, a vector, and/or a host cell comprising a nucleic acid encoding said hybrid protein for the preparation of a medicament for the prevention or treatment of transmissible spongiform encephalopathies (TSEs). Furthermore, the present invention is directed to a process for producing said hybrid proteins and it also relates to transgenic animals stably expressing said hybrid protein, the bone marrow of said transgenic animals and the use of said bone marrow for the treatment of transmissible spongiform encephalopathies (TSEs).
La présente invention concerne une protéine hybride soluble, comprenant au moins une première séquence polypeptidique dérivée d'une protéine prion PrP?c¿ pouvant fixer une protéine responsable d'une encéphalite spongiforme transmissible (PrP?sc¿), ainsi qu'une seconde séquence polypeptidique (étiquette), ladite protéine hybride ne comprenant pas de fraction d'ancrage à la membrane fonctionnelle. L'invention porte également sur l'utilisation de ladite protéine hybride pour le diagnostic d'encéphalopathies spongiformes transmissibles. Par ailleurs, l'invention concerne l'utilisation de ladite protéine hybride, d'un acide nucléique codant pour ladite protéine hybride, d'un vecteur et/ou d'une cellule hôte comprenant un acide nucléique codant pour ladite protéine hybride pour préparer un médicament destiné à prévenir ou traiter des encéphalopathies spongiformes transmissibles (EST). L'invention concerne enfin un procédé de production de ladite protéine hybride, ainsi que des animaux transgéniques exprimant de manière stable ladite protéine hybride, la moelle osseuse de ces animaux transgéniques et l'utilisation de cette moelle osseuse pour traiter des encéphalopathies spongiformes transmissibles (EST).
Aguzzi Adriano
Genoud Nicolas
Raeber Alex
Robic
University Of Zuerich
LandOfFree
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