C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/71 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2313348
The present invention relates to cDNA encoding a soluble neuropilin protein (sNP) which is isolated from neuropilin (NP) producing cells or is recombinantly engineered from NP-encoding DNA. NP-1 and NP-2 are preferred NPs but any neuropilin or VEGF receptor (VEGFR), where the constituents share at least about 85 % homology with either of the above VEGF165R/NP-1 and NP-2. More preferably, such constituent shares at least 90 % homology. Still more preferably, each constituent shares at least 95 % homology.
L'invention porte sur de l'ADNc codant pour une neuropiline soluble (sNP) isolée à partir de cellules génératrices de neurophiline (NP), ou recombinée par génie génétique à partir d'ADN codant pour une NP. Les NP préférées sont la NP-1 et la NP-2, mais toute neuropiline ou tout récepteur du VEGF (VEGFR) dont les constituants présentent 85 % d'homologie avec lesdites VEGF¿165?R/NP-1 et NP-2, ou mieux 90 %, ou mieux encore 95 %, peut être utilisé.
Gagnon Michael L.
Klagsbrun Michael
Soker Shay
Children's Medical Center Corporation
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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