Soluble interleukin-20 receptor

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/715 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2395539

A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

L'invention concerne un récepteur soluble de l'IL-20 comprenant deux sous-unités polypeptidiques, IL-20RA (anciennement désignée sous le nom de ZcytoR7) et IL-20RB (anciennement désignée sous le nom de DIRS1). Les deux sous-unités sont, de préférence, liées l'une à l'autre. Dans un mode de réalisation, une sous-unité est scellée à la région constante de la chaîne légère d'une immunoglobuline, et l'autre sous-unité est scellée à la région constante de la chaîne lourde de l'immunoglobuline. La chaîne légère et la chaîne lourde sont connectées par une liaison disulfure.

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