Soluble n.sub.2 substituted derivatives of 2,4-...

Details Soluble n.sub.2 substituted derivatives of 2,4-... Soluble n.sub.2 substituted derivatives of 2,4-...

C - Chemistry, Metallurgy

07

D

260/262.5

C07D 239/49 (2006.01) C07D 239/48 (2006.01)

Patent

CA 1180015

ABSTRACT OF THE DISCLOSURE Novel soluble N2 substituted derivatives of 2,4-diamino-5-benzyl pyrimidines as well as processes for their production are provided herein. These derivatives correspond to the general formula III below: (III) Image in which R1, R2, R3, R4 which may be identical or different, represent a hydrogen atom, a halogen atom or an alkyl, thioakyl, alkoxy, benzyloxy-, or alkyloxyalkoxy group; Y represents a hydrogen atom, an alkali metal or a pharmaceutically compatible organic base, and R represents a hydrogen atom or a linear or branched alkyl radical containing from 1 to 7 carbon atoms, a cycloalkyl radical containing from 5 to 8 carbon atoms, phenyl, a methylene dioxy ring or an ethylene dioxy ring, or a 5- or 6-membered hetero- cyclic ring, in which the heterocyclic atom is N, S or O, e.g. furane, thiophene, or pyridine. Such novel soluble N2 substituted derivatives are powerful anti-bacterial agents.

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