Soluble notch-based substrates for gamma secretase and...

Details Soluble notch-based substrates for gamma secretase and... Soluble notch-based substrates for gamma secretase and...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/245 (2006.01) C07K 14/47 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2505764

The present invention is directed to novel soluble substrates for .gamma.- secretase. More particularly, the invention provides a soluble fusion polypeptide with a Notch segment containing the .gamma. -secretase-dependent cleavage sites (.gamma. and .epsilon.) fused to a NusA protein. Methods and compositions for making and using such a fusion protein are disclosed.

L'invention concerne de nouveaux substrats solubles pour la sécrétase .gamma.. Plus particulièrement, l'invention concerne un polypeptide de fusion soluble comprenant un segment Notch qui contient les sites de clivage (.gamma. et e) dépendant de la sécrétase .gamma., fusionné avec une protéine NusA. Des procédés et des compositions permettant de fabriquer et d'utiliser une telle protéine de fusion sont décrits.

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