Soluble receptor br43x2 and methods of using

Details Soluble receptor br43x2 and methods of using Soluble receptor br43x2 and methods of using

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/17 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2358520

Soluble, secreted tumor necrosis factor receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise one cysteine-rich repeat that is homologous to other tumor necrosis factor receptors, such as transmembrane activator and CAML- interactor (TACI). The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides may also be used in methods that modulate B cell activation.

Cette invention concerne des polypeptides récepteurs de facteurs de nécrose tumorale sécrétés solubles, les polynucléotides codant pour les polypeptides, et les compositions et procédés correspondants. Lesdits polypeptides comprennent une séquence peptidique répétée riche en cystéine, homologue à d'autres facteurs de nécrose tumorale, tels que les activateurs transmembranaires et les agents d'interaction avec le ligand de cyclophiline et de modulateur de calcium (CAML-interactor / TACI). Lesdits polypeptides peuvent être utilisés pour détecter les ligands, les agonistes et les antagonistes. Lesdits polypeptides peuvent également être utilisés dans des procédés de modulation de l'activation des lymphocytes B.

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