Soluble salts of ibuprofen and naproxen with...

Details Soluble salts of ibuprofen and naproxen with... Soluble salts of ibuprofen and naproxen with...

C - Chemistry, Metallurgy

07

D

C07D 295/088 (2006.01) A61K 31/19 (2006.01) A61K 31/205 (2006.01) A61K 31/40 (2006.01) C07C 57/30 (2006.01) C07C 59/64 (2006.01)

Patent

CA 2072407

ABSTRACT The salts, in the crystalline form, of ibuprofen and naproxen with N-(2-hydroxyethyl) pyrrolidine are prepared by dissolving ibuprofen and naproxen respectively in a suitable organic solvent, by adding N-(2-hydroxyethyl) pyrrolidine, by letting the compounds react, by removing the solvent and by crystallizing the obtained salt from a solution in an apolar and aprotic solvent. Said salts have a high solubility in water and are used for preparing pharmaceutic compositions for oral and other administrations.

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