Soluble t cell receptor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/725 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2457652

The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all for part of a TCR .alpha. chain, except the transmembrane domain thereof, and (ii) all or part of a TCR .beta. chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain residues which is not present in native TCR.

Cette invention se rapporte à un récepteur de lymphocytes T soluble (TCRs), qui comprend: (i) une chaîne .alpha. de TCR en totalité ou partiellement, à l'exception de son domaine transmembranaire; et (ii) une chaîne .beta. de TCR en totalité ou en partie, à l'exception de son domaine transmembranaire. Les constituants (i) et (ii) contiennent chacun un domaine variable fonctionnel et au moins une partie du domaine constant de la chaîne de TCR et ils sont liés par une liaison disulfure entre les résidus du domaine constant, cette liaison n'étant pas présente dans le récepteur TCR natif.

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