Soluble virus-specific t-cell receptor compositions

Details Soluble virus-specific t-cell receptor compositions Soluble virus-specific t-cell receptor compositions

C - Chemistry, Metallurgy

07

K

C07K 4/00 (2006.01) A61K 38/00 (2006.01) C07K 7/00 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2648403

Compositions and methods for diagnosing a viral infection and methods of inhibiting such an infection are described. The methods are based on the identification of T-cell receptor gene sequences from cytotoxic T cell clones that are specific for HIV-I or HCV. Soluble T-cell receptor compositions that bind to HLA class I-restricted of HIV and HCV pathogens were identified and constructed.

L'invention concerne des compositions et des méthodes destinées à diagnostiquer une infection virale ainsi que des méthodes d'inhibition de cette infection. Les méthodes sont basées sur l'identification de séquences de gènes de récepteurs de lymphocytes T provenant de clones de lymphocytes T cytotoxiques spécifiques pour le VIH-1 ou le VHC. On a identifié et fabriqué des compositions à base de récepteurs de lymphocytes T solubles se liant à des agents pathogènes du VIH et du VHC à restriction par les molécules HLA de classe I.

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