Solution and crystal structures of mmp-13 active site and...

Details Solution and crystal structures of mmp-13 active site and... Solution and crystal structures of mmp-13 active site and...

G - Physics

01

N

G01N 9/00 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) G01N 33/48 (2006.01)

Patent

CA 2401063

The present invention relates to the three dimensional structure of human collagenase 3 (MMP-13), as well as to (i) methods of using the MMP-13 structure to rationally design or identify compounds or molecules that inhibit or activate MMP-13 activity, and (ii) compounds identified using said methods.

L'invention concerne la structure tridimensionnelle de la collagénase 3 (MMP-13) humaine, ainsi que (i) des procédés consistant à utiliser cette structure MMP-13 pour la conception rationnelle ou l'identification de composés ou de molécules qui inhibent ou activent l'activité de MMP-13, et (ii) des composés identifiés au moyen de ces procédés.

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