Solution containing igf-1

Details Solution containing igf-1 Solution containing igf-1

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 9/08 (2006.01) A61K 38/30 (2006.01) A61K 47/02 (2006.01)

Patent

CA 2153787

The invention relates to solutions containing IGF-1 or any functional analogue thereof in which pH is 5.5 to 6.5, preferably 5.7 to 6.2. The amount of phosphate as buffer substance should be in a concentration of less than 50 mmol/L. Preferably the formulation is an aqueous solution of IGF-1 and phosphate as buffer substance in a concentration of 5 to 50 mmol/L or more preferably 5-20 mmol/L,, e.g. mmol/L. The solution should be isotonic. The solution gives a reduced pain upon subcutaneous injection. The invention also relates to a process for preparation of the formulation by mixing IGF-1 or any functional analogue thereof with a buffer substance giving pH 5.5 to 6.5 and an isotonic agent. It also relates to a method for treatment of a patient in need of IGF-1 or any functional analogue thereof by administering the claimed formulation.

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