Solution for the preservation of hearts

Details Solution for the preservation of hearts Solution for the preservation of hearts

A - Human Necessities

01

N

A01N 1/00 (2006.01) A01N 1/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2383324

The present invention is directed to preservation solutions for storing and perfusing a heart intended for transplantation to a patient requiring such implant. It was found that when cyclosporin is added to the preservation solution for to: (1) preserve the mitochondrial function which it does by maintaining adenosine triphosphate ("ATP") levels, and (2) to block apoptosis and prevent programmed cell death. Therefore, the preservation of the mitochondrial function prevents necrosis while blocking prevents apoptosis.

L'invention concerne des solutions de conservation servant à conserver et à perfuser un coeur destiné à la transplantation. On a découvert que l'apport de cyclosporine à la solution de conservation: (1) préserve la fonction mitochondriale par maintien des niveaux de triphosphate d'adénosine ("ATP"), et (2) bloque l'apoptose et empêche la mort cellulaire programmée. De ce fait, la préservation de la fonction mitochondriale empêche la nécrose, tandis que le blocage évite l'apoptose.

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