A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/22 (2006.01) A61K 9/08 (2006.01) A61K 9/19 (2006.01) A61K 31/19 (2006.01) A61K 31/63 (2006.01) A61K 47/02 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2351273
A solution of N-[o-(p-pivaloyloxybenzenesulfonylamino) benzoyl]glycine monosodium salt tetra-hydrate (I) comprising at least one pH adjuster selected from tri-sodium phosphate, a hydrate thereof, sodium hydroxide or potassium hydroxide and a drug product using the solution. According to the invention, the solubility of the compound (I) increases and thereby it is possible to provide a solution thereof and a drug product using it. Moreover, by using a mixture of water and an organic solvent, greatly improved solubility makes it possible to manufacture a solution of higher concentration of the compound (I), and high-dosage drug products using it.
Solution de sel monosodique de N-¬o-(p-pivaloyloxybenzènesulfonylamino)benzoyl|glycine tétrahydraté (I) contenant au moins un ajusteur de pH parmi le phosphate trisodique, un hydrate de celui-ci, l'hydroxyde de sodium ou l'hydroxyde de sodium, ainsi que médicament faisant appel à cette solution. Selon l'invention, la solubilité du composé (I) s'accroît et, par conséquent, il est possible d'obtenir une solution de celui-ci ainsi qu'un médicament y faisant appel. En outre, l'utilisation d'un mélange d'eau et d'un solvant organique augmente considérablement la solubilité, ce qui rend possible la fabrication d'une solution à forte concentration du composé (I), ainsi que de médicaments en fortes doses faisant appel à celle-ci.
Sudoh Masao
Takada Akira
Ono Pharmaceutical Co. Ltd.
Sim & Mcburney
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