Solutions for tissue engineering and methods of use

Details Solutions for tissue engineering and methods of use Solutions for tissue engineering and methods of use

C - Chemistry, Metallurgy

12

N

C12N 5/07 (2010.01) C12N 5/071 (2010.01) C12N 5/077 (2010.01) C07K 14/78 (2006.01)

Patent

CA 2727625

The present invention provides for solutions and methods of preparing a decellularized tissue for recellularization The solutions provide collagen conditioning to restore collagen triple helix structure, strengthening of the collagen structure of the tissue, and biologically preparing the decellularized tissue by placing it in an environment that promotes recellularization Meth-ods and solutions for recellularization of a decellularized tissue, in accordance with the present invention, are also provided.

Cette invention concerne des solutions et des procédés de préparation d'un tissu décellularisé à des fins de recellularisation. Les solutions selon l'invention permettent le conditionnement du collagène pour restaurer la structure en triple hélice du collagène, le renforcement de la structure collagène du tissu, et la préparation biologique du tissu décellularisé par placement dans un environnement qui favorise la recellularisation. Des procédés et des solutions pour la recellularisation d'un tissu décellularisé, selon la présente invention, sont également décrits.

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