A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 1/02 (2006.01) A61K 33/06 (2006.01) A61K 35/14 (2006.01) A61K 38/06 (2006.01) A61K 38/38 (2006.01)
Patent
CA 2167409
A blood substitute which contains a purge solution and a maintenance solution, the latter of which is useful for organ preservation is disclosed. The purge solution contains an aqueous solution of electrolytes at physiological concentrations, a macromolecular oncotic agent, a biological pH buffer, a simple sugar, and a substrate for the regeneration of ATP. The maintenance solution contains a second aqueous solution of electrolytes containing potassium ions (35-45 mM), sodium ions (80-120 mM), magnesium ions (2-10 mM), chloride ions (15-20 mM), and calcium ions (0.01-0.1 mM), an impermeant anion, mannitol, a macromolecular oncotic agent, at least one simple sugar, a substrate for the regeneration of ATP, and a biological pH buffer. Glutathione is an optional additive. The blood substitute solutions are also useful for preserving organs for later transplantation in subjects. Skin may be preserved in the maintenance solutions for extended periods under refrigeration.
L'invention concerne un substitut de sang contenant une solution de purge et une solution de conservation efficace pour la préservation d'organes. La solution de purge contient une solution aqueuse d'électrolytes à des concentrations physiologiques, un agent oncotique macromoléculaire, un tampon de pH biologique, un sucre simple et un substrat de régénération d'ATP. La solution de conservation contient une deuxième solution aqueuse d'électrolytes comportant des ions potassium (35-45 mM), des ions sodium (80-120 mM), des ions magnésium (2-10 mM), des ions chlorure (15-20 mM) et des ions calcium (0,01-0,1 mM), un anion imperméable, du mannitol, un agent oncotique macromoléculaire, au moins un sucre simple, un substrat de régénération d'ATP et un tampon de pH biologique. Le glutathion est un additif éventuel. Les solutions de substitution sanguine sont également efficaces pour la préservation d'organes préalablement à leur transplantation chez un sujet. On peut conserver la peau dans les solutions de conservation pendant des durées prolongées sous réfrigération.
Blake Cassels & Graydon Llp
Cryomedical Sciences Inc.
LandOfFree
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