Solvate of cabergoline and preparations of cabergoline form i

Details Solvate of cabergoline and preparations of cabergoline form i Solvate of cabergoline and preparations of cabergoline form i

C - Chemistry, Metallurgy

07

D

C07D 457/06 (2006.01)

Patent

CA 2616738

A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and a p-disubstituted benzene of formula (A) and obtaining cabergoline Form I from the solvate. Another aspect of the present invention provides a method for preparing cabergoline Form I comprising dissolving cabergoline in p-disubstituted benzene and recovering the cabergoline Form I polymorph, suitably by direct crystallization of Form I or by recovery of a solvate which can be converted to Form I.

L'invention concerne un procédé de préparation de la forme I de cabergoline, consistant à former un solvate comprenant de la cabergoline et un benzène p-disusbtitué de formule (A) et à obtenir la forme I de cabergoline à partir de ce solvate. Un autre aspect de cette invention concerne un procédé de préparation de la forme I de cabergoline, comprenant les étapes consistant à dissoudre la cabergoline dans du benzène p-disubstitué puis à récupérer le polymorphe de forme I de cabergoline de façon adaptée par cristallisation directe de la forme I ou par récupération d'un solvate pouvant être converti en forme I.

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