Solvent-cast microneedle arrays containing active

Details Solvent-cast microneedle arrays containing active Solvent-cast microneedle arrays containing active

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2686093

In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Dans un aspect de l'invention, on forme un réseau de microsaillies en dotant un moule de cavités correspondant au négatif des microsaillies, en coulant au-dessus du moule une première solution comprenant un matériau biocompatible et un solvant, en éliminant le solvant, en coulant une seconde solution au-dessus de la première solution coulée, en éliminant le solvant de la seconde solution, et en démoulant le réseau résultant du moule. La première solution contient, de préférence, un ingrédient actif.

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