Solvent free amorphous rapamycin

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 498/18 (2006.01) C07D 221/00 (2006.01) C07D 273/00 (2006.01) C07D 311/00 (2006.01)

Patent

CA 2578245

An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents.

L'invention concerne un procédé amélioré d'enrobage de dispositifs médicaux comprenant l'utilisation de différents processus permettant d'accroître la stabilité des agents thérapeutiques contenus dans l'enrobage. La stabilité des agents thérapeutiques est améliorée par la création de formes amorphes sensiblement exemptes de solvant.

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