Solvent system for enhancing the solubility of...

A - Human Necessities – 61 – K

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A61K 9/48 (2006.01)

Patent

CA 2600023

Liquid and semi-solid pharmaceutical compositions, which can be administered in liquid form or can be used for preparing capsules, are described herein. The composition comprises the salt of one ore more active agents, polyethylene glycol, 0.2-1.0 mole equivalents of a de-ionizing agent per mole of active agent, and water. The pH of the composition is adjusted within the range of 2.5 - 7.5. The de-ionizing agent causes partial de- ionization (neutralization) of the salt of the active agent resulting in enhanced bioavailability of salts of weakly acidic, basic or amphoteric active agents as well as lesser amounts of polyethylene glycol (PEG) esters.

La présente invention concerne des compositions pharmaceutiques liquides et semi-solides, qui peuvent être administrées sous forme liquide ou utilisées pour la préparation de gélules. La composition comprend un sel d~un ou de plusieurs agents actifs, du polyéthylène glycol, 0,2-1,0 équivalent molaire d~un agent de désionisation par mole de principe actif, ainsi que de l~eau. Le pH de la composition est ajusté dans une fourchette comprise entre 2,5 et 7,5. L~agent de désionisation induit une désionisation (neutralisation) partielle du sel du principe actif, avec pour résultat une biodisponibilité accrue des sels des agents actifs amphotères, basiques ou faiblement acides ainsi que de moindres quantités d'esters de polyéthylène glycol (PEG).

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