Solventless process for making 2,6-difluorobenzonitrile

Details Solventless process for making 2,6-difluorobenzonitrile Solventless process for making 2,6-difluorobenzonitrile

C - Chemistry, Metallurgy

07

C

C07C 253/30 (2006.01) C07C 255/50 (2006.01)

Patent

CA 2209141

A process for making 2,6-difluorobenzonitrile, comprising reacting 2,6- dichlorobenzonitrile with a substantially anhydrous metal fluoride at a temperature between about 160 ~C and about 300 ~C and in the presence of a phase transfer catalyst, which is typically a polyether, tetra-substituted phosphonium salt, tetra-substituted ammonium salt, and cryptand, but in the absence of a solvent. After taking off the product the resulting mixture may be recycled into the reactor for the next reaction cycle. Upon build-up of tars in the reaction process, the invention includes the separation of catalyst from the tars and the recycle thereof.

Procédé de fabrication de 2,6-difluorobenzonitrile qui consiste à faire réagir du 2,6-difluorobenzonitrile avec un fluorure de métal pratiquement anhydre à une température s'échelonnant d'environ 160 ·C à environ 300 ·C et en présence d'un catalyseur par transfert de phase, typiquement un polyéther, de sel de phosphonium tétra-substitué, de sel ammoniac tétra-substitué, et d'un agent cryptant, mais sans avoir recours à un dissolvant. Après avoir retiré le produit, le mélange obtenu peut se recycler dans le réacteur pour le cycle de réaction suivant. L'invention comprend également, à l'apparition de goudrons lors du processus de réaction, la séparation du catalyseur et des goudrons et le recyclage de celui-ci.

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