A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/70 (2006.01) C07K 14/61 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2181170
This invention relates to somatic gene therapy to cells associated with fluid spaces, such as follicles of the thyroid, the synovium of the joint, the vitreous of the eye and the inner or middle ear. Formulated DNA expression vectors are introduced with or without formulation elements into fluid spaces under conditions in which cells associated with the fluid space can incorporate the formulated DNA expression vector. Formulated DNA expression-mediated gene therapy allows treatment of diseases involving cells associated with fluid spaces.
L'invention porte sur la thérapie par gènes somatiques visant des cellules associées à des espaces liquides tels que les follicules de la thyroïde, la synoviale des articulations, l'humeur vitrée de l'oeil ou de l'oreille interne ou médiane. Des vecteurs d'expression d'ADN formulé sont introduits avec ou sans éléments de formulation dans les espaces liquides dans des conditions dans lesquelles les cellules associées à ces espaces liquides peuvent incorporer le vecteur d'expression d'ADN formulé. La thérapie par gènes par expression d'ADN formulé permet le traitement d'affections touchant des cellules associées aux espaces liquides.
Ledley Fred D.
O'malley Bert W. Jr.
Baylor College Of Medicine
Smart & Biggar
LandOfFree
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