Somatostatin agonists

Details Somatostatin agonists Somatostatin agonists

A - Human Necessities

61

K

A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/55 (2006.01) C07D 205/02 (2006.01) C07D 209/08 (2006.01) C07D 209/18 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 498/16 (2006.01) C07D 513/16 (2006.01)

Patent

CA 2285604

This invention relates to somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. Compounds of formula (I) including pharmaceutically acceptable salts and hydrates thereof are disclosed. These compounds are useful in the treatment of diabetes, cancer, acromegaly, restenosis, depression, irritable bowel syndrome, pain and diabetic retinopathy. Many of the compounds are also orally active.

Composés agonistes de la somatostatine puissants, présentant une sélectivité élevée vis-à-vis du récepteur de sous-type 2. L'invention porte sur les composés de la formule (I), ainsi que sur les sels et hydrates pharmaceutiquement acceptables de ces composés. Ces composés sont utiles dans les traitement du diabète, du cancer, de l'acromégalie, de la resténose, de la dépression, du côlon irritable, de la douleur et de la rétinopathie diabétique. Un grand nombre de ces composés sont également actifs par voie orale.

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