A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/55 (2006.01) A61K 38/05 (2006.01) C07D 205/02 (2006.01) C07D 209/18 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07K 5/097 (2006.01)
Patent
CA 2287293
This invention relates to somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. Compounds of formula (I) including pharmaceutically acceptable salts and hydrates thereof are disclosed. These compounds are useful in the treatment of diabetes, cancer, acromegaly, restenosis, depression, irritable bowel syndrome, pain and diabetic retinopathy. Many of the compounds are also orally active.
L'invention porte sur des composés de formule (I) agonistes de la stomatostatine, très puissants et d'une grande sélectivité vis à vis du sous-type du récepteur 2, et sur leurs sels et hydrates pharmacocompatibles. Ces composés s'avèrent utiles pour le traitement du diabète, du cancer, de l'acromégalie, de la resténose, de la dépression, du côlon irritable, de la douleur, et de la rétinopathie diabétique, et la plupart sont efficaces par voie orale.
Berk Scott
Chapman Kevin
Chen Meng Hsin
Guo Liangqin
Johnston David
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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