Somatostatin agonists

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/55 (2006.01) A61K 38/05 (2006.01) C07D 205/02 (2006.01) C07D 209/18 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07K 5/097 (2006.01)

Patent

CA 2287293

This invention relates to somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. Compounds of formula (I) including pharmaceutically acceptable salts and hydrates thereof are disclosed. These compounds are useful in the treatment of diabetes, cancer, acromegaly, restenosis, depression, irritable bowel syndrome, pain and diabetic retinopathy. Many of the compounds are also orally active.

L'invention porte sur des composés de formule (I) agonistes de la stomatostatine, très puissants et d'une grande sélectivité vis à vis du sous-type du récepteur 2, et sur leurs sels et hydrates pharmacocompatibles. Ces composés s'avèrent utiles pour le traitement du diabète, du cancer, de l'acromégalie, de la resténose, de la dépression, du côlon irritable, de la douleur, et de la rétinopathie diabétique, et la plupart sont efficaces par voie orale.

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