Somatostatin analogs having a substituted tryptophyl residue...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/655 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1107273

AHP-7308 SOMATOSTATIN ANALOGS HAVING A SUBSTITUTED TRYPTOPHYL RESIDUE IN POSITION EIGHT Abstract of the Disclosure Tetradecapeptides of the formula Image in which A represents L, D or DL 5- or 6- fluoro, bromo-,chloro- or iodo- tryptophyl, or a therapeutically acceptable acid addition salt thereof, their preparation and intermediates for their preparation are disclosed. The tetradecapeptides are useful for inhibiting the release of growth hormone. Compositions and methods for their use also are disclosed.

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