Somatostatin antagonists and agonists that act at the sst...

Details Somatostatin antagonists and agonists that act at the sst... Somatostatin antagonists and agonists that act at the sst...

C - Chemistry, Metallurgy

07

K

C07K 5/078 (2006.01) A61K 38/05 (2006.01) A61P 5/06 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/068 (2006.01) C07K 5/083 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2345569

Compounds according formula (I) ~A-G-Z-W and pharmaceutically acceptable salts, solvates or hydrates thereof; wherein, A is (C6-C10)aryl, (C6-C10)aryl-SO2, (C6-C10)aryl-CH2-, (C6-C10)arylcarbonyl, (C1- C9)heteroaryl, (C1-C9)heteroaryl-SO2-, (C1-C9)heteroaryl-CH2-; or (C1- C9)heteroarylcarbonyl; G is selected from the group consisting of: (see formula I) where B is (C6-C10)aryl or (C1-C9)heteroaryl, and X is CH2, SO2, or carbonyl; (see formula II) where X is CH2, SO2, or carbonyl; and R1 and R1' are each independently selected from H, CN, (C1-C8)alkyl-, and phenyl(CH2)-, wherein said alkyl and phenyl groups are optionally substituted; and (see formula III); where Z and W are as defined in the present Specificiation; and pharmaceutical compositions and methods useful to increase secretion of growth hormone(GH) from the anterior pituitary of mammals, including on a sustained release basis.

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