Somatostatin receptor 2 antagonists

Details Somatostatin receptor 2 antagonists Somatostatin receptor 2 antagonists

C - Chemistry, Metallurgy

07

K

C07K 14/655 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2721470

Described herein are somatostatin analogs that are receptor antagonists of the somatostatin receptor, including SSTR2-selective antagonists. Related compounds, kits and methods, including antagonists complexed with or conjugated to radioactive nuclides and uses thereof. The antagonists of the invention are useful in diagnosing and treating neoplastic and non-neo-plastic mammalian diseases.

Cette invention concerne des analogues de la somatostatine qui sont des antagonistes du récepteur de la somatostatine, y compris les antagonistes SSTR2-sélectifs. Cette invention concerne des composés, des kits et des méthodes associés, y compris des antagonistes réduits en complexes avec ou conjugués à des nucléides radioactifs et leurs utilisations. Les antagonistes de linvention sont utilisés dans le diagnostic et le traitement des maladies néoplasiques et non néoplasiques chez le mammifère.

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