Somatostatin receptors

Details Somatostatin receptors Somatostatin receptors

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2127262

The invention relates generally to compositions of and methods for obtaining somatostatin receptors. The invention relates as well to the DNA sequences encoding somatostatin receptors, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant somatostatin receptor polypeptides. By way of example, the invention discloses th cloning and functional expression of at least three different somatostatin receptors, SSTR1, SSTR2 and SSTR3 from two different mammalian sources. The invention includes as well, methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with somatostatin receptor polypeptides for use in diagnostic, drug design and therapeutic applications.

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