Somatotropins with alterations in the alpha-helix 3 region,...

Details Somatotropins with alterations in the alpha-helix 3 region,... Somatotropins with alterations in the alpha-helix 3 region,...

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) C07K 1/113 (2006.01) C07K 14/61 (2006.01) C12N 15/10 (2006.01) C12N 15/64 (2006.01)

Patent

CA 2056564

31,297-00 SOMATOTROPINS WITH ALTERATIONS IN THE ALPHA-HELIX 3 REGION, ALPHA-HELIX 2 REGION COMBINATIONS THEREREOF, AND IN COMBINATION WITH OTHER MUTATIONS ABSTRACT OF THE INVENTION The present invention relates to somatotropin analogues with amino acid changes in the .alpha.-helix 3 regions of said somatotropins, changes in the .alpha.-helix 2 regions, combinations thereof plus combinations with other changes to the native amino acid sequence of somatotropins. The resulting analogues are stable for formulation in sustained release formulations, while maintaining biological activity. Further, methods for conducting site-directed mutagenesis on DNA encoding proteins and/or polypeptides also are provided.

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