C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/497 (2006.01) A61P 1/04 (2006.01) A61P 11/00 (2006.01) A61P 19/00 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2703996
The invention provides certain novel 6-heteroaryl-5-methyl-3-oxo-4- [3(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide derivatives and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitord of human neutrophil elastase.
L'invention porte sur certains nouveaux dérivés de 6-hétéroaryl-5-méthyl-3-oxo-4-[3(trifluorométhyl)phényl]-3,4-dihydropyrazine-2-carboxamide, des sels pharmaceutiquement acceptables et des formes particulières de ceux-ci ; conjointement avec des procédés permettant de les préparer, des compositions pharmaceutiques les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs de l'élastase des neutrophiles humains.
Ainge Debra
Chapman David
Lindsjoe Martin
Loenn Hans
Lundkvist Michael
Astrazeneca Ab
Fetherstonhaugh & Co.
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