Somnogenic activity of non-pathogenic lactic acid bacteria

Details Somnogenic activity of non-pathogenic lactic acid bacteria Somnogenic activity of non-pathogenic lactic acid bacteria

A - Human Necessities

61

K

A61K 35/74 (2006.01) A23C 9/123 (2006.01) A23C 11/10 (2006.01) A23L 1/03 (2006.01) A61P 25/20 (2006.01)

Patent

CA 2394802

Non-pathogenic lactic acid bacteria have cell walls which are susceptible to digestion by muramidase-type enzymes, which produce fragments referred to as muramylpeptides. The ingestion of muramylpeptides, either directly, or by digestion of non-pathogenic lactic acid bacteria, promote sleep and improves the quality of sleep. In particular, non-rapid eye movement sleep phase enhanced. The muramylpeptide digestion-products of non-pathogenic lactic acid bacteria promote monocyte production of superoxide anion and the cytokines of IL-1.beta. and TNF.alpha..

L'invention concerne des bactéries lactiques non pathogènes comprenant des parois cellulaires sensibles à une digestion par des enzymes de type muramidase qui produisent des fragments désignés sous le nom de muramylpeptides. L'ingestion des muramylpeptides, soit directement, soit par digestion des bactéries lactiques non pathogènes, favorise le sommeil et augmente la qualité du sommeil. En particulier, la phase de sommeil à mouvements occulaires lents est améliorée. Les produits de la digestion des muramylpeptides des bactéries non pathogènes favorisent la production de monocytes d'anion superoxyde et des cytokines de IL-1.beta. et TNF.alpha..

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