Sophorae subprostratae radix extract for prevention and...

A - Human Necessities – 61 – K

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Details

A61K 36/489 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2585657

The present invention relates to an extract isolated from Sophorae Radix useful for prevention and treatment of respiratory diseases. More specifically, the present invention relates to a pharmaceutical drug comprising the Sophorae Radix extract having excellent effects of inhibiting airway contraction, respiratory infections, 5-lipoxygenase activity, phosphodiesterase 4 activity, airway hyper-responsiveness and airway remodeling; antagonistic activity against leukotriene D4; and an antitussive effect, thus being useful for prevention and treatment of respiratory diseases such as asthma, acute or chronic bronchitis, allergic rhinitis, acute upper respiratory infections and acute lower respiratory infections, and the like.

La présente invention se rapporte à un extrait isolé de Sophorae subprostratae Radix utile pour la prévention et le traitement de maladies respiratoires. Plus spécifiquement, la présente invention se rapporte à un médicament pharmaceutique comprenant l'extrait de Sophorae subprostratae Radix et présentant d'excellents effets d'inhibition de la contraction des voies aériennes, des infections respiratoires, de l'activité 5-lipoxygénase, de l'activité phosphodiestérase 4, de l'hyperréactivité des voies aériennes et du remodelage des voies aériennes; de l'activité antagoniste dirigée contre du leucotriène D4; ainsi qu'un effet antitussif, ledit médicament s'avérant par conséquent utile pour la prévention et le traitement des maladies respiratoires telles que l'asthme, la bronchite aiguë ou chronique, la rhinite allergique, les infections respiratoires supérieures aiguës et les infections respiratoires inférieures aiguës, et analogues.

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