Sox-9 gene and protein and use in the regeneration of bone...

Details Sox-9 gene and protein and use in the regeneration of bone... Sox-9 gene and protein and use in the regeneration of bone...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2206305

An isolated DNA molecule encoding a Sox-9 gene which codes for the Sox-9 polypeptide. The human Sox-9 gene has been mapped to chromosome 17 in the same region as CMPD-1, the locus for Campomelic Dysplasia (CD). Sox-9 appears to have a role in mammalian skeletal development, and is used in the treatment of diseases involving bone or cartilage deficiency.

Molécule isolée d'ADN contenant un gène Sox-9 qui code pour le polypeptide Sox-9. Chez l'homme, le gène Sox-9 a été cartographié sur le chromosome 17, dans la même région que le CMPD-1, c'est-à-dire le locus de la dysplasie camptomélique. Le Sox-9 joue un rôle dans le développement du squelette chez les mammifères et peut être utilisé dans le traitement des maladies impliquant une déficience osseuse ou cartilagineuse.

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