Sox modulators in the treatment of alopecia

Details Sox modulators in the treatment of alopecia Sox modulators in the treatment of alopecia

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2737983

The invention relates to an in vitro method for screening candidate compounds for the preventive or curative treatment of alopecia, said method comprising the determination of the capacity of a compound to modulate the expression or the activity of a SOX transcription factor, and the use of modulators of the expression or the activity of said transcription factor for the treatment of alopecia. The invention also relates to methods for the in vitro diagnosis or prognosis of said pathology

L'invention concerne une méthode in vitro de criblage de composés candidats pour le traitement préventif ou curatif de l'alopécie, comprenant la détermination de la capacité d'un composé à moduler l'expression ou l'activité d'un facteur de transcription SOX, ainsi que l'utilisation de modulateurs de l'expression ou de l'activité de ce facteur de transcription pour le traitement de l'alopécie. L'invention concerne aussi des méthodes de diagnostic ou pronostic in vitro de cette pathologie.

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