Soybean-based biomaterials

C - Chemistry – Metallurgy – 08 – H

Patent

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Details

C08H 1/00 (2006.01) A61K 47/46 (2006.01) A61L 15/40 (2006.01) A61L 27/22 (2006.01) A61L 27/36 (2006.01) A61L 31/00 (2006.01) A61L 31/04 (2006.01)

Patent

CA 2456006

The invention provides thermoplastic materials for biomedical applications through the processing of soybean de-fatted Tofu cheese. The material films show a relatively high degree of water uptake from the dry state as well as good tensile strength and elastic modulus when tested in wet conditions. The materials minimisein vitro the humoral and cell-mediated inflammatory response, promote the formation of calcium phosphate crystals and undergo a slow degradation in buffer systems. Adhesion and proliferation of tissue cells are also favoured by this natural composite material.

Cette invention concerne des matériaux thermoplastiques pour applications biomédicales, obtenus par le traitement de fromage de Tofu à base de soja dégraissé. Les films de ce matériau présentent un degré relativement élevé d'absorption d'eau à l'état sec, ainsi qu'une bonne résistance à la traction et d'un bon coefficient d'élasticité lorsqu'ils sont testés dans des conditions d'humidité. Ces matériaux réduisent au maximum les réactions inflammatoires humorales et à médiation cellulaire in vitro, activent la formation de cristaux de phosphate de calcium et subissent une dégradation lente dans les systèmes tampon. Ce matériau composite naturel favorise également l'adhésion et la prolifération des cellules tissulaires.

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