Sparc-derived tumor rejection antigenic peptides and...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/47 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2655361

The object is to identify a peptide derived from SPARC protein which can induce a human cytotoxic (killer) T cell and a helper T cell both reactive to a tumor, and to provide a means for enabling a tumor immunotherapy in a cancer patient having a high level of SPARC expression. Disclosed is a peptide (A) or (B): (A) a peptide which comprises an amino acid sequence depicted in any one of SEQ ID NOs:1-3; and (B) a peptide which comprises an amino acid sequence having the substitution or addition of one or several amino acid residues in a peptide comprising an amino acid sequence depicted in any one of SEQ ID NOs:1-3 and which can induce a killer T cell.

La présente invention concerne l'identification d'un peptide dérivé de la protéine SPARC qui peut induire un lymphocyte T cytotoxique humain (tueur) et un lymphocyte T auxiliaire, tous deux étant réactifs face à une tumeur. L'invention concerne également l'élaboration d'un moyen permettant une immunothérapie tumorale chez un patient cancéreux présentant un niveau élevé d'expression de SPARC. L'invention concerne un peptide (A) ou (B). (A) est un peptide qui comporte une séquence d'acides aminés décrite dans l'une quelconque des séquences SEQ ID NO 1 à 3, et (B) est un peptide qui comporte une séquence d'acides aminés contenant un ou plusieurs résidus d'acide aminé substitués ou ajoutés dans une séquence d'acides aminés décrite dans l'une quelconque des séquences SEQ ID NO 1 à 3 et capable d'induire un lymphocyte T tueur.

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