C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/118.5
C07D 499/24 (2006.01) C07D 499/00 (2006.01)
Patent
CA 1178948
D.P.C. (Ph) 6379 SPARINGLY WATER-SOLUBLE SALTS OF PENICILLANIC ACID 1,1-DIOXIDE Abstract The 1:2 N,N'-dibenzylethylenediamine, the N- benzyl-2-phenylethylamine and the dibenzylamine salts of penicillanic acid 1,1-dioxide, a well-known beta- lactamase inhibitor, are sparingly soluble in water. Accordingly they are valuable as slow release (depot) forms of penicillanic acid 1,1-dioxide, particularly for use in conjunction with slow release (depot) forms of penicillin and cephalosporin antibiotics, in the chemotherapy of bacterial infections in mammals.
395289
Armstrong William W.
Moppett Charles E.
Windisch Wendell W.
Limited Pfizer
Smart & Biggar
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