C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2460014
Compounds and methods for inducing protective immunity against cancer are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more SPAS-1 proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and pharmaceutical compositions for immunization against cancer , or can be used for the diagnosis of cancer and the monitoring of cancer progression.
L'invention concerne des composés et des méthodes permettant d'activer l'immunité protectrice contre le cancer. Ces composés comprennent des polypeptides contenant au moins une portion immunogénique d'une ou de plusieurs protéines SPAS-1 et des molécules d'ADN codant pour de tels polypeptides. De tels composés peuvent être préparés sous forme de vaccins et de compositions pharmaceutiques permettant l'immunisation contre le cancer, ou encore, ils peuvent être utilisés pour diagnostiquer un cancer et pour surveiller la progression d'un cancer.
Allison James P.
Fasso Marcella
Shastri Nilabh
Fetherstonhaugh & Co.
The Regents Of The University Of California
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