Spasmolytically active tertiary amine derivatives and method...

Details Spasmolytically active tertiary amine derivatives and method... Spasmolytically active tertiary amine derivatives and method...

C - Chemistry, Metallurgy

07

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260/277, 260/291

C07D 211/06 (2006.01) C07D 211/32 (2006.01) C07D 211/58 (2006.01) C07D 295/18 (2006.01) C07D 295/194 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1281321

ABSTRACT New spasmolytic active tertiary amine derivatives, salts thereof, and processes for their preparation, of the formula 1 are described Image 1 in which the groups R represent a range of possibilities, typically hydrogen or an alkyl or alkylene group; A is a phenyl or heteroaryl group having 5 or 6 members; Z is the group NR12 or an oxygen atom, R12 being hydrogen or alkyl; n is zero or 1; and X is a carbonyl, thiocarbonyl or SO2 group. In the compounds wherein R4 is other than hydrogen, the S-configuration of the chiral center is pre- ferred. A typical compound is Image These compounds do not exhibit the peripheral and central muscarino- lytic side effects characteristic of other neurotropic spasmolytics, for example atropine and secorerine.

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