Spasmolytics

Details Spasmolytics Spasmolytics

C - Chemistry, Metallurgy

07

D

260/353.3, 260/5

C07D 317/14 (2006.01) C07D 317/28 (2006.01)

Patent

CA 1060457

ABSTRACT OF THE DISCLOSURE Tertiary amines of formula Image (3) wherein R1 represents methoxy, hydrogen, chlorine or fluorine; R2 represents hydrogen, or when R1 is hydrogen, R2 may be methoxy; R3 repre- sents methyl; R4 represents ethyl; R5 represents branched or straight alkylene having from 3 to 9 carbon atoms; R6 represents branched or straight alkyl having from 1 to 5 carbon atoms, or cyclohexyl; X repre- sents oxygen, or ethylene dioxy; and the pharmaceutically acceptable acid addition salts thereof have a strong and prolonged spamolytic effect, also after oral administration, on the smooth musculature of the tractus gastrointestinalis, the tractus urogenitalis and the bronchial system and have a low toxicity. The compounds can be synthetized according to methods known per se and be enformulated to pharmaceutical compositions.

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