Spatially-defined macrocyclic compounds useful for drug...

Details Spatially-defined macrocyclic compounds useful for drug... Spatially-defined macrocyclic compounds useful for drug...

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) C07K 1/04 (2006.01) C07K 5/08 (2006.01)

Patent

CA 2533818

Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.

L'invention concerne des nouveaux composés macrocycliques définis spatialement contenant des éléments de contrôle conformationnel spécifiques. Des banques de ces macrocycles sont utilisées pour sélectionner une ou plusieurs espèces de macrocycles présentant une interaction spécifique avec une cible biologique particulière. Plus particulièrement, les composés de l'invention sont utilisés comme agonistes ou antagonistes d'un récepteur de motiline de mammifère et d'un récepteur de ghréline de mammifère.

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