Specialized antibody treatment for brain neoplasm

Details Specialized antibody treatment for brain neoplasm Specialized antibody treatment for brain neoplasm

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/26 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2149731

A method of treating malignant brain cells, and pharmaceutical composition therefor, by transporting or injecting into the area of those cells at least one monoclonal antibody which specifically reacts with an epitope present on the carboxy-terminal peptide of the beta (.beta.) subunit of human chorionic gonadotropin. The antibody(ies) may be carried across the blood-brain barrier by stereotactic injection, or may be administered intraarterially (intracarotid administration, for example) in conjunction with an osmotic agent which allows at least some of the monoclonal antibody(ies) to pass the blood-brain barrier. Three examples of this class of monoclonal antibodies--CTP101, CTP102 and CTP103--have been administered in an established animal model to show efficacy of treatment of human brain cancer.

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