C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/42 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2478346
The invention relates to specific anti-anti-idiotypic antibodies which react with anti-idiotypic antibodies which represent an internal image of antigen CA125 and which also bind themselves to the antigen, i.e. are specific for the tumour-associated antigen CA125. The invention relates in particular to a CA125-specific anti-anti-idiotypic antibody which reacts with anti-idiotypic anti-body ACA125. The invention further relates to pharmaceutical compositions containing said anti-anti-idiotypic antibodies for treating CA125-expressed tumours, especially ovarian cancer.
Anticorps anti-anti-idiotypiques spécifiques réagissant avec des anticorps anti-idiotypiques qui représentent une image interne de l'antigène CA125 et se lient à l'antigène lui-même, c'est-à-dire qui sont spécifiques de l'antigène CA125 associé aux tumeurs. La présente invention concerne en outre un anticorps anti-anti-idiotypique spécifique de CA125 qui réagit avec l'anticorps anti-idiotypique ACA125. Elle concerne encore des compositions pharmaceutiques contenant ces anticorps anti-anti-idiotypiques pour le traitement de tumeurs exprimant CA125, en particulier des carcinomes ovariens.
Schlebusch Harald
Wagner Uwe
Cellcontrol Biomedical Laboratories Ag
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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