C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 19/34 (2006.01) C12N 15/87 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2645045
The present invention provides a method of selectively amplifying fetal DNA sequences from a mixed, fetal-maternal source. This method utilizes differential methylation to allow for the selective amplification of trophoblast/fetal specific sequences from DNA mixtures that contain a high proportion of non- trophoblast/fetal DNA. The invention also provides methods of using the amplified fetal DNA sequences for aneuploidy detection.
L'invention concerne un procédé destiné à amplifier de manière sélective des séquences d'ADN foetal à partir d'une source foetal maternelle, mélangée. Ce procédé utilise la méthylation différentielle afin de permettre l'amplification sélective de séquences trophoblaste/foetal spécifiques de mélanges d'ADN qui contiennent une proportion élevée d'ADN foetal/non trophoblaste. L'invention concerne également des procédés utilisant des séquences d'ADN foetal amplifiées dans la détection d'aneuploïdie.
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University In The City Of New York
LandOfFree
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