C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/26 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/58 (2006.01) C07K 16/06 (2006.01) C12N 5/12 (2006.01) C12N 5/20 (2006.01) G01N 33/53 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2494140
The invention relates to in vitro diagnosis of heart failure. More specifically, the invention relates to specific antibodies of a peptide domain which is situated on either side of hinge region R76S77 of proBNP(1-108). In particular, the invention relates to a method of obtaining the aforementioned antibodies and to the use thereof in detecting blood proBNP(1-108) with the exception of BNP(1-76) and BNP(77-108). The invention also relates to a method of detecting blood proBNP(1-108), reagents and a kit for same.
L'invention concerne le domaine du diagnostic in vitro de l'insuffisance cardiaque. L'invention concerne plus particulièrement des anticorps spécifiques d'un domaine peptidique situé de part et d'autre de la zone charnière R76S77 du proBNP(1-108). L'invention concerne plus particulièrement un procédé d'obtention de ces anticorps et leur utilisation pour détecter le proBNP(1-108) sanguin à l'exclusion du BNP(1-76) et du BNP(77-108). L'invention concerne aussi un procédé de détection du proBNP(1-108) sanguin, des réactifs et une trousse pour le mettre en oeuvre.
Giuliani Isabelle
Pau Bernard
Rieunier Francois
Bio-Rad Pasteur
Centre National de La Recherche Scientifique (c.n.r.s.)
Robic
Universite Montpellier I.
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