C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/30 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2239519
Sequence and binding information is provided for particularly advantageous specific binding members which bind human carcinoembryonic antigen (CEA) with a dissociation constant which is less than 1,0 × 10 -8M, are substantially non-cross-reactive with human liver cells, bind to the A3-B3 extracellular domain of human carcinoembryonic antigen and/or bind to cell-associated human carcinoembryonic antigen preferentially over soluble human carcinoembryonic antigen. These are useful particularly in determination of CEA expression by cells such as tumour cells.
L'invention concerne des informations de séquence et de liaison concernant des éléments de liaison spécifiques particulièrement intéressants, qui fixent l'antigène carcinonembryonnaire humain (ACE) avec une constante de dissociation inférieure à 1,0x10<-8> M, qui ne présentent pratiquement pas de réaction croisée avec les cellules hépatiques humaines, et qui se lient au domaine extracellulaire A3-B3 de l'antigène carcinoembryonnaire humain, et/ou à l'antigène carcinoembryonnaire humain associé aux cellules, de préférence par le biais de l'antigène carcinoembryonnaire humain soluble. Ces éléments sont particulièrement utiles pour déterminer l'expression de l'ACE par des cellules telles que des cellules tumorales.
Allen Deborah Julie
Mccafferty John Gerald
Osbourn Jane Katharine
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cambridge Antibody Technology Limited
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