Specific binding members for ngf

Details Specific binding members for ngf Specific binding members for ngf

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01) C07K 14/48 (2006.01) C07K 16/22 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2595800

Specific binding members for Nerve Growth Factor (NGF), in particular anti-NGF antibody molecules, especially human antibody molecules, and especially those that neutralise NGF activity. Methods for using anti-NGF antibody molecules in diagnosis or treatment of NGF related disorders, including pain, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, other diseases of airway inflammation, diabetic neuropathy, cardiac arrhythmias, HIV, arthritis, psoriasis and cancer.

La présente invention concerne des éléments de liaison spécifiques du facteur de croissance des nerfs (NGF), en particulier des molécules d'anticorps anti-NGF, tout particulièrement des molécules d'anticorps humaines, et notamment celles qui neutralisent l'activité du NGF. L'invention concerne en outre des procédés d'utilisation de molécules d'anticorps anti-NGF dans le diagnostic ou le traitement de troubles liés au NGF, notamment la douleur, l'asthme, la broncho-pneumopathie chronique obstructive, la fibrose pulmonaire, d'autres maladies d'inflammation des voies respiratoires, la neuropathie diabétique, les arythmies cardiaques, le VIH, l'arthrite, le psoriasis et le cancer.

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