Specific binding molecules for scintigraphy,conjugates...

Details Specific binding molecules for scintigraphy,conjugates... Specific binding molecules for scintigraphy,conjugates...

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2333833

The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabeled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and suitable photoactive molecules (e.g. a judiciously chosen photosensitizer), and their use for the selective light- mediated occlusion of new blood vesels.

L'invention concerne des anticorps présentant une affinité sub-nanomolaire spécifique pour un épitope du domaine ED-B de la fibronectine, un marqueur de l'angiogenèse. L'invention concerne en outre l'utilisation d'anticorps anti ED-B à forte affinité, marqués isotopiquement, pour la détection in vivo de la formation de nouveaux vaisseaux sanguins et un kit de diagnostic comprenant cet anticorps. L'invention concerne en outre des conjugués comprenant ces anticorps et des molécules photosensibles adaptées (p. ex. un photosensibilisant choisi judicieusement), ainsi que l'utilisation de ceux-ci pour une occlusion sélective des nouveaux vaisseaux sanguins par application de lumière.

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